Blog | Polaris Oligos

Stability-inducing modifications in oligonucleotides

Oligonucleotides are short sequences of nucleic acids that are widely used in several biotechnological applications, such as gene...

All about oligos impurities and side reactions

Synthetic oligonucleotides have applications in a variety of scientific disciplines, and considerable effort has been put towards their...

How to deal with Sodium and Potassium Ions in Oligos Analysis by Mass Spectrometry

Metal ions such as sodium (Na) and potassium (K) are commonly found in biological samples. They can have a significant impact on the...

Harnessing HILIC separations for Oligonucleotide Analysis: A Comprehensive Guide and Practical Tips

In the context of oligonucleotide analysis, it can be challenging to distinguish shorter sequences resulting from coupling failure from...

Synthetic scales and yields

Polaris oligonucleotides offer various scale options to meet your quantity needs. For DNA, synthetic scales from 0.2 - 10 umol can be...

All about oligos desalting!

During the process of oligonucleotide synthesis, purification, or storage, oligos can become contaminated with salts, which can interfere...

Beware of counterions!

DNA counterions